Pairings shown with regional seed. All games on Friday, November 15, at 7 p.m.
Higher seeded team is the designated home team and listed first.
Division I
Region 1
1. Mentor (12-0) vs. 5. Canton McKinley (8-4) at Medina High School Ken Dukes Stadium
3. Perrysburg (10-2) vs. 7. Lakewood St. Edward (7-5) at Elyria High School Mercy Field at Ely Stadium
Region 2
vs. 5. Hilliard Davidson (8-4) vs. 8. Huber Heights Wayne (7-5) at Miami Trace High School Tony’s Welding and Fabrication Stadium
2. Centerville (9-3) vs. 14. Dublin Coffman (4-8) at Springfield High School Wildcat Stadium
Region 3
1. Powell Olentangy Liberty (10-2) vs. 5. Upper Arlington (10-2) at Westerville Central High School
6. Delaware Olentangy Berlin (10-2) vs. 7. Pickerington North (10-2) at Columbus St. Francis DeSales Alumni Stadium
Region 4
1. Cincinnati Archbishop Moeller (11-1) vs. 4. Cincinnati Princeton (10-2) at Mason High School Tri-Health/Beacon Stadium
2. West Chester Lakota West (11-1) vs. 6. Cincinnati St. Xavier (9-3) at Cincinnati Princeton High School Jake Sweeney Automotive Stadium
Division II
Region 5
1. Cuyahoga Falls Walsh Jesuit (12-0) vs. 4. Austintown-Fitch (9-3) at Ravenna High School Portage Community Bank Stadium Harry Gilchrist Field
2. Akron Archbishop Hoban (10-2) vs. 3. Macedonia Nordonia (10-2) at Barberton High School Sharkey Stadium
Region 6
1. Avon (12-0) vs. 5. Wadsworth (11-1) at Strongsville High School Pat Catan Stadium
2. Medina Highland (12-0) vs. 3. Whitehouse Anthony Wayne (12-0) at Bellevue High School First National Bank Field
Region 7
1. Sunbury Big Walnut (11-1) vs. 4. Ashland (12-0) at Marion Harding High School Ohio Health Field at Harding Stadium
3. Massillon Washington (9-2) vs. 7. Ashville Teays Valley (8-4) at Zanesville High School Sulsberger Stadium
Region 8
1. Cincinnati Anderson (12-0) vs. 5. Cincinnati Mount Healthy (9-2) at Lakota East High School
2. Cincinnati La Salle (10-2) vs. 6. Harrison (10-2) at Hamilton Ross High School
Division III
Region 9
1. Youngstown Ursuline (11-1) vs. 4. Aurora (11-1) at North Canton Hoover High School Memorial Stadium
2. Gates Mills Gilmour Academy (11-1) vs. 3. Cuyahoga Falls CVCA (10-2) at Twinsburg High School Tiger Stadium
Region 10
1. Toledo Central Catholic (11-1) vs. 12. Lexington (7-5) at Tiffin Columbian Frost-Kalnow Stadium
3. Cleveland Benedictine (10-2) vs. 7. Parma Padua Franciscan (7-5) at North Royalton High School Serpentini Stadium
Region 11
1. Columbus Bishop Watterson (12-0) vs. 4. Newark Licking Valley (11-1) at Licking Heights High School Hornet Stadium
2. Steubenville (11-0) vs. 11. Dover (9-3) at Carrollton High School Warrior Stadium
Region 12
4. London (12-0) vs. 8. St. Marys Memorial (10-2) at Piqua High School Alexander Stadium
2. Wapakoneta (12-0) vs. 3. Bellbrook (11-1) at Troy High School Memorial Stadium
Division IV
Region 13
1. Mentor Lake Catholic (12-0) vs. 5. Cleveland Glenville (9-3) at Painesville Riverside High School
2. Perry (11-1) vs. 3. Streetsboro (12-0) at Burton Berkshire High School Great Lakes Cheese Stadium
Region 14
1. Sandusky Perkins (11-1) vs. 13. Napolean (7-5) at Milbury Lake High School Community Stadium
2. Shelby (12-0) vs. 3. Ontario (11-1) at Mansfield Arlin Field
Region 15
1. St. Clairsville (12-0) vs. 13. Millersburg West Holmes (7-5) at New Philadelphia High School Quaker Stadium
2. Gnadenhutten Indian Valley (12-0) vs. 3. New Lexington (11-1) at Coshocton High School Stewart Field
Region 16
5. Cincinnati Taft (10-2) vs. 9. Cincinnati Indian Hill (9-3) at Milford High School Eagle Stadium Powered by Cullen Electric
6. Cleves Taylor (10-2) vs. 10. Kettering Archbishop Alter (7-5) at Fairfield High School Christy Rose Dennis Stadium
Division V
Region 17
1. Canfield South Range (12-0) vs. 5. Sugarcreek Garaway (10-2) at Minerva High School Dr. Robert Hines Stadium
2. Akron Manchester (11-1) vs. 3. Poland Seminary (10-2) at Louisville High School Leopard Stadium
Region 18
1. Milan Edison (12-0) vs. 5. Pemberville Eastwood (11-1) at Clyde High School Robert J. Bishop Jr. Stadium
2. Liberty Center (12-0) vs. 3. Oak Harbor (12-0) at TBA
Region 19
1. Ironton (11-1) vs. 4. Canal Winchester Harvest Prep (9-2) at Waverly High School Raidiger Field
7. Zanesville West Muskingum (9-2) vs. 14. Wheelersburg (8-4) at Athens Joe Burrow Stadium
Region 20
1. Jamestown Greeneview (12-0) vs. 5. Lewistown Indian Lake (10-2) at Fairborn High School Skyhawk Stadium
2. West Liberty-Salem (11-1) vs. 3. Waynesville (9-3) at Dayton Welcome Stadium
Division VI
Region 21
1. Kirtland (12-0) vs. 4. Columbia Station Columbia (10-2) at Brooklyn High School Coach Jerry Younger Field
2. New Middletown Springfield (10-2) vs. 6. Dalton (9-3) at Alliance Marlington High School
Region 22
1. Bascom Hopewell-Loudon (11-0) vs. 4. Hamler Patrick Henry (10-2) at Findlay Donnell Stadium
2. Bluffton (11-1) vs. 3. Toledo Ottawa Hills (10-1) at Defiance High School Fred Brown Athletic Complex
Region 23
1. Columbus Grandview Heights (11-0) vs. 4. Beverly Fort Frye (9-3) at Logan High School Chieftain Stadium
2. Galion Northmor (12-0) vs. 3. West Lafayette Ridgewood (11-1) at Newark White Field
Region 24
1. Coldwater (11-1) vs. 5. St. Bernard Elmwood Place (10-2) at Trotwood-Madison High School Miami Valley Hospital SportsPlex
2. Cincinnati Country Day (11-1) vs. 3. Anna (9-3) at Monroe High School Hornet Stadium
Division VII
Region 25
5. Warren John F. Kennedy (10-2) vs. 9. Cuyahoga Heights (7-4) at Orwell Grand Valley High School
2. Jeromesville Hillsdale (11-1) vs. 3. Malvern (11-1) at Massillon Perry High School Wakefield Stadium
Region 26
1. Columbus Grove (12-0) vs. 4. Sycamore Mohawk (10-2) at Fostoria High School Memorial Stadium
11. Leipsic (8-4) vs. 15. Delphos St. John’s (5-7) at Ottawa-Glandorf High School Titan Stadium
Region 27
1. Danville (10-2) vs. 5. Corning Miller (10-2) at Thornville Sheridan High School Paul Culver Jr. Stadium
2. Beaver Eastern (12-0) vs. 3. Bowerston Conotton Valley (9-3) at Heath High School Swank Field
Region 28
1. Maria Stein Marion Local (12-0) vs. 4. Ansonia (11-1) at Lima Spartan Stadium
2. Minster (10-2) vs. 3. Cincinnati College Prep (9-2) at Sidney High School Memorial Stadium
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