Division I
Region 1
1 Lakewood St. Edward (11-1) vs. 6 Medina (9-3) at Parma Byers Field at Robert Boulton Stadium
Region 2
6 Dublin Coffman (9-3) vs. 12 Springfield (8-5) at Hilliard Darby High School
Region 3
2 Hilliard Bradley (12-1) vs. 4 Upper Arlington (10-3) at Historic Crew Stadium
Region 4
3 Wester Chester Lakota West (11-2) vs. 5 Cincinnati Archbishop Moeller (9-4) at Mason Tri-Health/Beacon Stadium
Division II
Region 5
1 Akron Archbishop Hoban (11-1) vs. 2 Cuyahoga Falls Walsh Jesuit (12-1) at University of Akron InfoCision Stadium
Region 6
1 Avon (13-0) vs. 3 Medina Highland (11-2) at Strongsville Pat Catan Stadium
Region 7
1 Massillon Washington (13-0) vs. 3 Uniontown Green (10-3) at North Canton Hoover Memorial Stadium
Region 8
1 Cincinnati Anderson (12-1) vs. 3 Cincinnati Withrow (12-1) at Cincinnati Princeton Jake Sweeney Automotive Stadium
Division III
Region 9
1 Youngstown Ursulina (13-0) vs. 7 Chardon (10-3) at Ravenna Portage Community Bank Stadium, Harry Gilchrist Field
Region 10
1 Toledo Central Catholic (13-0) vs. 3 Tiffin Columbian (11-2) at Clyde Robert J. Bishop Jr. Stadium
Region 11
1 Columbus Bishop Watterson (12-1) vs. 7 Bellefontaine (11-2) at Marion Ohio Health Field at Harding Stadium
Region 12
1 Hamilton Badin (13-0) vs. 6 Celina (11-2) at Trotwood-Madison Miami Valley Hospital SportsPlex
Division IV
Region 13
1 Canton South (13-0) vs. 6 Struthers (10-3) at Tallmadge Larry Bagnoli Stadium
Region 14
1 Sandusky Perkins (12-0) vs. 2 Cleveland Glenville (10-2) at Elyria Mercy Field at Ely Stadium
Region 15
1 Steubenville (12-1) vs. 2 Thornville Sheridan (12-1) at New Philadelphia Quaker Stadium
Region 16
4 Kettering Archbishop Alter (10-3) vs. 6 Cincinnati Wyoming (12-1) at Monroe Hornet Stadium
Division V
Region 17
1 Perry (13-0) vs. 2 Canfield South Range (12-1) at Twinsburg Tiger Stadium
Region 18
1 Liberty Center (13-0) vs. 6 Coldwater (12-1) at Lima Spartan Stadium
Region 19
4 Canal Winchester Harvest Prep (11-1) vs. 7 Wheelersburg (9-3) at Athens Joe Burrow Stadium
Region 20
1 Germantown Valley View (12-1) vs. 2 Waynesville (11-2) at Springboro CareFlight Field at Watkins Stadium
Division VI
Region 21
1 Kirtland (12-1) vs. 3 Mogadore (10-2) at Macedonia Nordonia Boliantz Stadium
Region 22
1 Columbus Grove (11-2) vs. 2 Bluffton (12-1) at Findlay Donnell Stadium
Region 23
1 Sugarcreek Garaway (13-0) vs. 2 West Jefferson (12-1) at Zanesville Sulsberger Stadium
Region 24
2 Versailles (11-2) vs 8 Anna (8-5) Sidney Memorial Stadium
Division VII
Region 25
1 Dalton (11-1) vs. 2 Danville (13-0) at Dover Crater Stadium
Region 26
5 Hamler Patrick Henry (11-2) vs. 6 McComb (11-2) at Napoleon Buckenmeyer Stadium
Region 27
1 Reedsville Eastern (12-1) vs. 3 Caldwell (10-3) at Vincent Warren Warrior Stadium
Region 28
1 Maria Stein Marion Local (13-0) vs. 2 Ansonia (13-0) at Piqua High School Alexander Stadium
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